Sick building syndrome, also known as building-related illness, is a controversial subject shrouded in mystery, hearsay, and conflicting arguments. The fact that there are no diagnostic tests and specific treatments for it stirs even more confusion. What is clear, though, is that many people seem to succumb to illnesses as the result of exposure to a host of biological, physical, and chemical agents present in residential and commercial buildings. Therefore, sick building syndrome can be considered an umbrella term for multifarious risk factors and symptoms that occur in indoor environments. And no matter how we choose to call them, rest assured that they are real.